What does TopoSNP provide?
TopoSNP provides a online resource for analyzing missense SNPs
that can be mapped onto known 3D structures of proteins.
TopoSNP also provides disease information derived from the Online Mendelian
Inheritance in Man (OMIM) database, protein family information from Pfam database.
TopoSNP further classifies whether the missense SNP site located at pocket region
of protein.
Users can utilize HGNC gene symbol, rsSNP ID, uniProt ID or PDB ID to request
a search.
How does TopoSNP classify geometric location for proteins?
Residues in protein structure can contribute to three geometric
locations:
a. those located in pockets of the protein.
b. those on surface region.
c. those that are completely buried in the interior
of the protein structure. These buried residues show zero Solvent accessibility surface area.
Any Questions?
Contact bwang54@uic.edu.