SPRI: Structure-Based Pathogenicity Relationship Identifier for Missense Mutations

Select the Data Source for Querying
  • Uniprot ID

Examples of Querying SPRI
Uniprot O00244
Uniprot P0C6T2
Statistics for SPRI Database Mutation Saturation Predictions for AlphaFold2 human proteome is expected to be released soon.
One protein sequence can be mapped to several non-overlapping PDB chains. Under Creative Commons NonCommercial license (CC BY-NC)
Data Resource Number of Entries Release
Uniprot 5,821 June 2022
PDB Chain 8,821 June 2022
Acknowledgement
This project is supported by NIH grant R01CA204962
Citation:
1. Wang, Boshen, et al. "Structure-Based Pathogenicity Relationship Identifier (SPRI): A Novel Structure-Guided Method to Evaluate Pathological Effect of Missense Mutations." Briefings in Bioinformatics, vol. 24, no. 4 (2023).
2. Wang, Boshen, Wei Tian, Xue Lei, Alan Perez-Rathke, Yan Yuan Tseng, and Jie Liang. "Structure-Based Method for Predicting Deleterious Missense SNPs." In 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI), pp. 1-4. IEEE, 2019.
Performance with Experimental-determined PDB Structures
Performance on unknown-PDB proteins using AlphaFold2 structures
© 2021 Liang Lab Copyright